ARHGAP10 - Rho GTPase-activating protein 10 - human protein (Function)
 
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Protein
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References

 
ARHGAP10 »  Rho GTPase-activating protein 10
 
Protein also known as:  GTPase regulator associated with focal adhesion kinase 2.
Gene name:  ARHGAP10
Entry whose protein(s) existence is based on evidence at protein level
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1 17 1
GENE REF ISO

Function

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Overview 
GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Rho GTPase activator activitydefinition[GO:0005100] silver  
  • IEAOrtholog Compara
GO biological process 
Cytoskeleton organizationdefinition[GO:0007010] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Positive regulation of Rho GTPase activitydefinition[GO:0032321] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Bacterial invasion of epithelial cells  hsa05100+79658  
According to Reactome, this protein belongs to the following pathways:
Regulation of PAK-2p34 activity by PS-GAP/RHG10  REACT_13528  
Rho GTPase cycle  REACT_11051  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 79658
PRO: PR:A1A4S6