ANO9 - Anoctamin-9 - human protein (Function)
 
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ANO9 »  Anoctamin-9
 
Protein also known as:  Tumor protein p53-inducible protein 5.
Gene name:  ANO9
Family name: Anoctamin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.  
4
  • UniProtKB
According to TCDB this is a transporter from family:
the calcium-dependent chloride channel (ca-clc) family  1.A.17.1.5  
GO molecular function 
Contradiction  Intracellular calcium activated chloride channel activitydefinition[GO:0005229]  
3
  • UniProtKB
Phospholipid scramblase activitydefinition[GO:0017128] silver  
1
  • Ortholog Compara
GO biological process 
Calcium activated galactosylceramide scramblingdefinition[GO:0061591] silver  
1
  • Ortholog Compara
Calcium activated phosphatidylcholine scramblingdefinition[GO:0061590] silver  
1
  • Ortholog Compara
Calcium activated phosphatidylserine scramblingdefinition[GO:0061589] silver  
1
  • Ortholog Compara
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • GOC
Chloride transportdefinition[GO:0006821]  
1
  • UniProtKB
Lipid transportdefinition[GO:0006869]  
1
  • UniProtKB KW
Negative regulation of intracellular calcium activated chloride channel activitydefinition[GO:1902939]  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Orphan transporters  REACT_267716  
Stimuli-sensing channels  REACT_160189  
Note 
The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.  
1
  • UniProtKB
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 338440
PRO: PR:A1A5B4