DENND3 - DENN domain-containing protein 3 - human protein (Function)
 
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DENND3 »  DENN domain-containing protein 3
 
Gene name:  DENND3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor.  
2
  • UniProtKB
GO molecular function 
Rab guanyl-nucleotide exchange factor activitydefinition[GO:0017112]  
1
  • UniProtKB
GO biological process 
Cellular protein catabolic processdefinition[GO:0044257]  
1
  • Ortholog Curator
Endosome to lysosome transportdefinition[GO:0008333]  
1
  • Ortholog Curator
Positive regulation of Rab GTPase activitydefinition[GO:0032851]  
2
  • GOC
  • Ortholog Compara
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 22898
PRO: PR:A2RUS2