FUOM - Fucose mutarotase - human protein (Function)
 
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FUOM »  Fucose mutarotase   [ EC 5.1.3.n2 ]
 
Gene name:  FUOM
Family name: RbsD / FucU
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.  
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  • CuratedUniProtKB
GO molecular function 
Fucose bindingdefinition[GO:0042806]  
  • ISSOrtholog Curator
Racemase and epimerase activity, acting on carbohydrates and derivativesdefinition[GO:0016857]  
  • ISSOrtholog Curator
GO biological process 
Fucose metabolic processdefinition[GO:0006004]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.1.3.-: Alpha-L-fucose beta-L-fucose.  
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  • CuratedUniProtKB
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 282969
PRO: PR:A2VDF0