CNOT1 - CCR4-NOT transcription complex subunit 1 - human protein (Function)
 
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CNOT1 »  CCR4-NOT transcription complex subunit 1
 
Protein also known as:  Negative regulator of transcription subunit 1 homolog (NOT1H).
Gene name:  CNOT1
Family name: CNOT1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.  
7
  • CuratedUniProtKB
GO molecular function 
Estrogen receptor bindingdefinition[GO:0030331]  
1
  • IDAUniProtKB
Contributes to poly(A)-specific ribonuclease activitydefinition[GO:0004535]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
Retinoic acid receptor bindingdefinition[GO:0042974]  
1
  • IDAUniProtKB
GO biological process 
Gene silencing by RNAdefinition[GO:0031047]  
  • IEAUniProtKB KW
Multicellular organismal developmentdefinition[GO:0007275]  
  • IEAUniProtKB KW
Negative regulation of intracellular estrogen receptor signaling pathwaydefinition[GO:0033147]  
1
  • IDAUniProtKB
Negative regulation of retinoic acid receptor signaling pathwaydefinition[GO:0048387]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAUniProtKB
Nucleic acid phosphodiester bond hydrolysisdefinition[GO:0090305]  
1
  • IDAGOC
Positive regulation of cytoplasmic mRNA processing body assemblydefinition[GO:0010606]  
1
  • IDAUniProtKB
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decaydefinition[GO:1900153]  
1
  • IMPUniProtKB
Positive regulation of nuclear-transcribed mRNA poly(A) tail shorteningdefinition[GO:0060213]  
1
  • IMPUniProtKB
Regulation of stem cell maintenancedefinition[GO:2000036]  
1
  • IMPUniProtKB
Regulation of translationdefinition[GO:0006417]  
  • IEAUniProtKB KW
RNA phosphodiester bond hydrolysisdefinition[GO:0090501]  
1
  • IDAGOC
RNA phosphodiester bond hydrolysis, exonucleolyticdefinition[GO:0090503]  
1
  • IDAGOC
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
RNA degradation  hsa03018+23019  
According to Reactome, this protein belongs to the following pathways:
Gene Expression  REACT_71  
Metabolism of RNA  REACT_21257  
 

Keywords

Biological process 
RNA-mediated gene silencing  definition   [KW-0943]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Translation regulation  definition   [KW-0810]
Molecular function 
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CNOT1
GenomeRNAi: 23019
PRO: PR:A5YKK6