CARNS1 - Carnosine synthase 1 - human protein (Function)
 
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Protein
Gene
References

 
CARNS1 »  Carnosine synthase 1   [ EC 6.3.2.11 ]
 
Protein also known as:  ATP-grasp domain-containing protein 1.
Gene name:  CARNS1
Entry whose protein(s) existence is based on evidence at protein level
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1 13 5
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activitydefinition[GO:0016887]  
1
  • IDAMGI
Carnosine synthase activitydefinition[GO:0047730]  
1
  • IDAMGI
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • IDAGOC
Carnosine biosynthetic processdefinition[GO:0035499]  
1
  • IDAMGI
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.2.11: ATP + L-histidine + beta-alanine ADP + phosphate + carnosine.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 manganese ions per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+57571  
beta-Alanine metabolism  hsa00410+57571  
Histidine metabolism  hsa00340+57571  
 

Biophysicochemical properties

Kinetic parameters
KM 4.67 mM for L-lysine
KM 7.66 mM for L-ornithine
KM 0.37 mM for L-histidine
KM 24.7 mM for N-methylhistidine
KM 1.84 mM for gamma-aminobutyrate
KM 0.09 mM for beta-alanine
Vmax 0.61 nmol/min/mg enzyme toward L-lysine
Vmax 0.76 nmol/min/mg enzyme toward L-histidine
Vmax 0.28 nmol/min/mg enzyme toward L-ornithine
Vmax 0.62 nmol/min/mg enzyme toward N-methylhistidine
Vmax 54.7 nmol/min/mg enzyme toward gamma-aminobutyrate
Vmax 65.3 nmol/min/mg enzyme toward beta-alanine

Keywords

Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 57571
PRO: PR:A5YM72