IZUMO1R - Sperm-egg fusion protein Juno - human protein (Function)
 
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IZUMO1R »  Sperm-egg fusion protein Juno
 
Protein also known as:  IZUMO1 receptor protein JUNO.
Gene name:  IZUMO1R
Family name: Folate receptor
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate (By similarity).  
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  • UniProtKB
GO molecular function 
Not  Folic acid bindingdefinition[GO:0005542]  
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  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
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  • UniProtKB
Receptor activitydefinition[GO:0004872]  
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  • UniProtKB
GO biological process 
Cell adhesiondefinition[GO:0007155]  
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  • Ortholog Curator
Fusion of sperm to egg plasma membranedefinition[GO:0007342]  
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  • Ortholog Curator
Single fertilizationdefinition[GO:0007338]  
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  • Ortholog Curator
Sperm-egg recognitiondefinition[GO:0035036]  
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  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Endocytosis  hsa04144+390243  
 

Keywords

Biological process 
Fertilization  definition   [KW-0278]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 390243
PRO: PR:A6ND01