FOLR4 - Sperm-egg fusion protein Juno - human protein (Function)
 
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Protein
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References

 
FOLR4 »  Sperm-egg fusion protein Juno
 
Protein also known as:  Folate receptor delta (FR-delta).
Gene name:  FOLR4
Family name: Folate receptor
Entry whose protein(s) existence is based on evidence at protein level
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1 8 2
GENE REF ISO

Function

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Overview 
Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for gamete recognition and fertilization. The IZUMO1:FOLR4/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Not  Folic acid bindingdefinition[GO:0005542]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Receptor activitydefinition[GO:0004872]  
1
  • IPIUniProtKB
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • ISSOrtholog Curator
Fusion of sperm to egg plasma membranedefinition[GO:0007342]  
  • ISSOrtholog Curator
Single fertilizationdefinition[GO:0007338]  
  • ISSOrtholog Curator
Sperm-egg recognitiondefinition[GO:0035036]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Endocytosis  hsa04144+390243  
 

Keywords

Biological process 
Fertilization  definition   [KW-0278]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 390243
PRO: PR:A6ND01