CAPN8 - Calpain-8 - human protein (Function)
 
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CAPN8 »  Calpain-8   [ EC 3.4.22.53 ]
 
Protein also known as:  Stomach-specific M-type calpain.
Gene name:  CAPN8
Family name: Peptidase C2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Calcium-dependent cysteine-type endopeptidase activitydefinition[GO:0004198] silver  
  • IBARefGenome
GO biological process 
Proteolysisdefinition[GO:0006508] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.53: Broad endopeptidase specificity.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 calcium ions (Potential).  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 388743
PRO: PR:A6NHC0