ARHGAP32 - Rho GTPase-activating protein 32 - human protein (Function)
 
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ARHGAP32 »  Rho GTPase-activating protein 32
 
Protein also known as:  RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling.
Gene name:  ARHGAP32
Entry whose protein(s) existence is based on evidence at protein level
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1 43 3
GENE REF ISO

Function

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Overview 
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation.  
7
  • CuratedUniProtKB
Isoform  Iso 2   Has higher GAP activity (By similarity).  
7
  • CuratedUniProtKB
GO molecular function 
GTPase activator activitydefinition[GO:0005096]  
  • IEAUniProtKB KW
Phosphatidylinositol bindingdefinition[GO:0035091] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Positive regulation of GTPase activitydefinition[GO:0043547]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Rho GTPase cycle  REACT_11051  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RICS_(gene)
GenomeRNAi: 9743
PRO: PR:A7KAX9