NEURL1B - E3 ubiquitin-protein ligase NEURL1B - human protein (Function)
 
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Protein
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References

 
NEURL1B »  E3 ubiquitin-protein ligase NEURL1B   [ EC 6.3.2.- ]
 
Protein also known as:  Neuralized-like protein 1B.
Gene name:  NEURL1B
Entry whose protein(s) existence is based on evidence at protein level
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1 5 3
GENE REF ISO

Function

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Overview 
E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.  
1
  • CuratedUniProtKB
GO molecular function 
Ligase activitydefinition[GO:0016874]  
  • IEAUniProtKB KW
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Notch signaling pathwaydefinition[GO:0007219]  
  • IEAUniProtKB KW
Protein ubiquitinationdefinition[GO:0016567]  
  • IEAUniPathway
Pathways 
This protein is involved in the following pathway
According to Reactome, this protein belongs to the following pathways:
Activated NOTCH1 Transmits Signal to the Nucleus  REACT_118614  
Constitutive Signaling by NOTCH1 HD Domain Mutants  REACT_160089  
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
NOTCH2 Activation and Transmission of Signal to the Nucleus  REACT_160205  
 

Keywords

Biological process 
Notch signaling pathway  definition   [KW-0914]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 54492
PRO: PR:A8MQ27