AHRR - Aryl hydrocarbon receptor repressor - human protein (Function)
 
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AHRR »  Aryl hydrocarbon receptor repressor  (AhRR)
 
Protein also known as:  Class E basic helix-loop-helix protein 77 (bHLHe77).
Gene name:  AHRR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.  
3
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB KW
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • InterPro 2 GO
RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001191]  
1
  • RefGenome
Signal transducer activitydefinition[GO:0004871] silver  
1
  • InterPro 2 GO
GO biological process 
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • RefGenome
Positive regulation of protein sumoylationdefinition[GO:0033235] silver  
1
  • Ortholog Compara
Not  Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • RefGenome
Response to xenobiotic stimulusdefinition[GO:0009410]  
1
  • RefGenome
Signal transductiondefinition[GO:0007165] silver  
1
  • InterPro 2 GO
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 57491
PRO: PR:A9YTQ3