AGPS - Alkyldihydroxyacetonephosphate synthase, peroxisomal - human protein (Function)
 
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Protein
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References

 
AGPS »  Alkyldihydroxyacetonephosphate synthase, peroxisomal   [ EC 2.5.1.26 ]  (Alkyl-DHAP synthase)
 
Protein also known as:  Alkylglycerone-phosphate synthase.
Gene name:  AGPS
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 1
GENE REF ISO

Function

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Overview 
Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Alkylglycerone-phosphate synthase activitydefinition[GO:0008609]  
2
  • IDAUniProtKB
  • IDAMGI
FAD bindingdefinition[GO:0071949]  
  • ISSOrtholog Curator
UDP-N-acetylmuramate dehydrogenase activitydefinition[GO:0008762] silver  
  • IEAInterPro 2 GO
GO biological process 
Ether lipid biosynthetic processdefinition[GO:0008611]  
  • ISSOrtholog Curator
  • IEAUniPathway
Lipid biosynthetic processdefinition[GO:0008610]  
1
  • IDAMGI
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.5.1.26: 1-acyl-glycerone 3-phosphate + a long-chain alcohol an alkyl-glycerone 3-phosphate + a long-chain acid anion.  
  • CuratedUniProtKB
It requires the following cofactor
FAD.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Ether lipid metabolism  hsa00565+8540  
Metabolic pathways  hsa01100+8540  
Peroxisome  hsa04146+8540  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 8540
PRO: PR:O00116