FZD9 - Frizzled-9 - human protein (Function)
 
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FZD9 »  Frizzled-9  (Fz-9)
 
Protein also known as:  FzE6; CD antigen CD349.
Gene name:  FZD9
Entry whose protein(s) existence is based on evidence at transcript level
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1 21 1
GENE REF ISO

Function

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Overview 
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
PDZ domain bindingdefinition[GO:0030165] silver  
  • IBARefGenome
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
Wnt-activated receptor activitydefinition[GO:0042813] silver  
  • IBARefGenome
Wnt-protein bindingdefinition[GO:0017147]  
1
  • IPIUniProtKB
GO biological process 
B cell differentiationdefinition[GO:0030183] silver  
  • IBARefGenome
Brain developmentdefinition[GO:0007420] silver  
  • IBARefGenome
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IBARefGenome
Gonad developmentdefinition[GO:0008406] silver  
  • IBARefGenome
Learning or memorydefinition[GO:0007611] silver  
  • IEAOrtholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Neuroblast proliferationdefinition[GO:0007405] silver  
  • IBARefGenome
Vasculature developmentdefinition[GO:0001944] silver  
  • IBARefGenome
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+8326  
HTLV-I infection  hsa05166+8326  
Melanogenesis  hsa04916+8326  
Pathways in cancer  hsa05200+8326  
Wnt signaling pathway  hsa04310+8326  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Caution 
Has been first described as FZD3 in literature.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FZD9
GenomeRNAi: 8326
PRO: PR:O00144