ACOT7 - Cytosolic acyl coenzyme A thioester hydrolase - human protein (Function)
 
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Protein
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ACOT7 »  Cytosolic acyl coenzyme A thioester hydrolase   [ EC 3.1.2.2 ]
 
Protein also known as:  Long chain acyl-CoA thioester hydrolase.
Gene name:  ACOT7
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 27 7
GENE REF ISO

Function

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Overview 
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.  
  • CuratedUniProtKB
GO molecular function 
Catalytic activitydefinition[GO:0003824]  
1
  • TASPINC
Fatty-acyl-CoA bindingdefinition[GO:0000062]  
1
  • TASPINC
Palmitoyl-CoA hydrolase activitydefinition[GO:0016290]  
  • IEAEC 2 GO
GO biological process 
Fatty acid catabolic processdefinition[GO:0009062] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.2.2: Palmitoyl-CoA + H(2)O CoA + palmitate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Biosynthesis of unsaturated fatty acids  hsa01040+11332  
Fatty acid elongation  hsa00062+11332  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Serine esterase  definition   [KW-0719]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: O00154
Other
GeneWiki: ACOT7
GenomeRNAi: 11332
PRO: PR:O00154