MYO1C - Unconventional myosin-Ic - human protein (Function)
 
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MYO1C »  Unconventional myosin-Ic
 
Protein also known as:  Myosin I beta (MMIb).
Gene name:  MYO1C
Entry whose protein(s) existence is based on evidence at protein level
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1 44 3
GENE REF ISO

Function

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Overview 
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity).  
  • CuratedUniProtKB
Isoform  Iso 3   Is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • IEAUniProtKB KW
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Motor activitydefinition[GO:0003774] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
  • IEAOrtholog Compara
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
GO biological process 
mRNA transportdefinition[GO:0051028]  
  • IEAUniProtKB KW
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IMPUniProtKB
Positive regulation of cell migration by vascular endothelial growth factor signaling pathwaydefinition[GO:0038089]  
1
  • IMPUniProtKB
Positive regulation of protein targeting to membranedefinition[GO:0090314]  
1
  • IMPUniProtKB
Positive regulation of vascular endothelial growth factor signaling pathwaydefinition[GO:1900748]  
1
  • IMPUniProtKB
Protein targetingdefinition[GO:0006605]  
1
  • IDAUniProtKB
Protein targeting to membranedefinition[GO:0006612]  
1
  • IDAUniProtKB
Regulation of tight junction assemblydefinition[GO:2000810]  
1
  • IMPUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
Membrane Trafficking  REACT_11123  
Caution 
Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Translocation  definition   [KW-0811]
Transport  definition   [KW-0813]
mRNA transport  definition   [KW-0509]
Molecular function 
Motor protein  definition   [KW-0505]
Myosin  definition   [KW-0518]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MYO1C
GenomeRNAi: 4641
PRO: PR:O00159