KCNK1 - Potassium channel subfamily K member 1 - human protein (Function)
 
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Protein
Gene
References

 
KCNK1 »  Potassium channel subfamily K member 1
 
Protein also known as:  Inward rectifying potassium channel protein TWIK-1.
Gene name:  KCNK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 21 1
GENE REF ISO

Function

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Overview 
Weakly inward rectifying potassium channel that contributes to the regulation of the resting membrane potential.  
3
  • UniProtKB
GO molecular function 
Inward rectifier potassium channel activitydefinition[GO:0005242]  
1
  • PINC
Potassium channel activitydefinition[GO:0005267]  
1
  • UniProtKB
Potassium ion leak channel activitydefinition[GO:0022841]  
1
  • RefGenome
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • UniProtKB
  • RefGenome
Potassium ion transportdefinition[GO:0006813]  
1
  • PINC
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Response to nicotinedefinition[GO:0035094] silver  
1
  • Ortholog Compara
Stabilization of membrane potentialdefinition[GO:0030322]  
1
  • RefGenome
Enzymatic activity 
It is regulated in the following manner
Inhibited by Ba(2+) ions, quinine and quinidine (PubMed8605869). Is not inhibited by 4-aminopyridine, charybdotoxin and dendrotoxin, and is only marginally inhibited by 10 mM TEA (PubMed8605869).  
2
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)  REACT_75779  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KCNK1
GenomeRNAi: 3775
PRO: PR:O00180