MASP2 - Mannan-binding lectin serine protease 2 - human protein (Function)
 
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MASP2 »  Mannan-binding lectin serine protease 2   [ EC 3.4.21.104 ]
 
Protein also known as:  Mannose-binding protein-associated serine protease 2 (MASP-2). Cleaved into:  Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain.
Gene name:  MASP2
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.  
1
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Calcium-dependent protein bindingdefinition[GO:0048306]  
1
  • IPIUniProtKB
Peptidase activitydefinition[GO:0008233]  
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  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252]  
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  • IDAUniProtKB
GO biological process 
Complement activation, classical pathwaydefinition[GO:0006958]  
  • IEAUniProtKB KW
Complement activation, lectin pathwaydefinition[GO:0001867]  
2
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.104: Selective cleavage after Arg-223 in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+10747  
Staphylococcus aureus infection  hsa05150+10747  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Complement pathway  definition   [KW-0180]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 10747
PRO: PR:O00187