AP3B1 - AP-3 complex subunit beta-1 - human protein (Function)
 
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References

 
AP3B1 »  AP-3 complex subunit beta-1
 
Protein also known as:  Clathrin assembly protein complex 3 beta-1 large chain.
Gene name:  AP3B1
Entry whose protein(s) existence is based on evidence at protein level
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1 48 2
GENE REF ISO

Function

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Overview 
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.  
  • CuratedUniProtKB
GO molecular function 
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • IPIUniProtKB
GO biological process 
Anterograde axon cargo transportdefinition[GO:0008089]  
  • ISSOrtholog Curator
Anterograde synaptic vesicle transportdefinition[GO:0048490]  
  • ISSOrtholog Curator
Antigen processing and presentation, exogenous lipid antigen via MHC class Ibdefinition[GO:0048007] silver  
  • IEAOrtholog Compara
Blood coagulationdefinition[GO:0007596] silver  
  • IEAOrtholog Compara
Intracellular protein transportdefinition[GO:0006886]  
1
  • TASPINC
Melanosome organizationdefinition[GO:0032438]  
1
  • IMPUniProtKB
Positive regulation of NK T cell differentiationdefinition[GO:0051138] silver  
  • IEAOrtholog Compara
Protein targeting to lysosomedefinition[GO:0006622] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+8546  
According to Reactome, this protein belongs to the following pathway:
Membrane Trafficking  REACT_11123  
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AP3B1
GenomeRNAi: 8546
PRO: PR:O00203