NDUFS8 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial - human protein (Function)
 
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NDUFS8 »  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial   [ EC 1.6.99.3EC 1.6.5.3 ]
 
Protein also known as:  NADH-ubiquinone oxidoreductase 23 kDa subunit.
Gene name:  NDUFS8
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.  
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GO molecular function 
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539]  
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  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
Contributes to NADH dehydrogenase (ubiquinone) activitydefinition[GO:0008137]  
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  • UniProtKB
Contributes to NADH dehydrogenase activitydefinition[GO:0003954]  
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  • UniProtKB
GO biological process 
Mitochondrial electron transport, NADH to ubiquinonedefinition[GO:0006120]  
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Mitochondrial respiratory chain complex I assemblydefinition[GO:0032981]  
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  • UniProtKB
Response to oxidative stressdefinition[GO:0006979]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.6.5.3: NADH + ubiquinone + 5 H(+)(In) NAD(+) + ubiquinol + 4 H(+)(Out).  
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EC 1.6.99.3: NADH + acceptor NAD(+) + reduced acceptor.  
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  • UniProtKB
It requires the following cofactor
 [4Fe-4S] cluster : Binds 2 [4Fe-4S] clusters per subunit.  
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  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+4728  
Huntington's disease  hsa05016+4728  
Metabolic pathways  hsa01100+4728  
Oxidative phosphorylation  hsa00190+4728  
Parkinson's disease  hsa05012+4728  
According to Reactome, this protein belongs to the following pathway:
Respiratory electron transport  REACT_22393  
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Respiratory chain  definition   [KW-0679]
Transport  definition   [KW-0813]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NDUFS8
GenomeRNAi: 4728
PRO: PR:O00217