BMPR1B - Bone morphogenetic protein receptor type-1B - human protein (Function)
 
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BMPR1B »  Bone morphogenetic protein receptor type-1B   [ EC 2.7.11.30 ]  (BMPR-1B)
 
Protein also known as:  CD antigen CDw293.
Gene name:  BMPR1B
Entry whose protein(s) existence is based on evidence at protein level
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1 55 2
GENE REF ISO

Function

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Overview 
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAHGNC
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIBHF-UCL
  • IPIHGNC
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAHGNC
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IEAInterPro 2 GO
SMAD bindingdefinition[GO:0046332]  
1
  • IDAHGNC
Transforming growth factor beta receptor activity, type Idefinition[GO:0005025] silver  
  • IEAOrtholog Compara
Transmembrane receptor protein serine/threonine kinase activitydefinition[GO:0004675]  
2
  • IMPUniProtKB
GO biological process 
BMP signaling pathwaydefinition[GO:0030509]  
2
  • IDABHF-UCL
  • NASUniProtKB
Cartilage condensationdefinition[GO:0001502]  
1
  • NASUniProtKB
Chondrocyte differentiationdefinition[GO:0002062] silver  
  • IEAOrtholog Compara
Dorsal/ventral pattern formationdefinition[GO:0009953] silver  
  • IEAOrtholog Compara
Eye developmentdefinition[GO:0001654]  
  • ISSOrtholog Curator
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Limb morphogenesisdefinition[GO:0035108]  
1
  • IMPUniProtKB
Ovarian cumulus expansiondefinition[GO:0001550]  
  • ISSOrtholog Curator
Ovulation cycledefinition[GO:0042698]  
  • ISSOrtholog Curator
Positive regulation of bone mineralizationdefinition[GO:0030501]  
1
  • IMPBHF-UCL
Positive regulation of cell differentiationdefinition[GO:0045597]  
1
  • IMPUniProtKB
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:1902043] silver  
  • IEAOrtholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • IMPBHF-UCL
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAHGNC
Retina development in camera-type eyedefinition[GO:0060041] silver  
  • IEAOrtholog Compara
Retinal ganglion cell axon guidancedefinition[GO:0031290] silver  
  • IEAOrtholog Compara
Skeletal system developmentdefinition[GO:0001501]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.30: ATP + [receptor-protein] ADP + [receptor-protein] phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium or manganese (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+658  
TGF-beta signaling pathway  hsa04350+658  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Chondrogenesis  definition   [KW-0891]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: BMPR1B
GenomeRNAi: 658
PRO: PR:O00238
Chemistry
GuidetoPHARMACOLOGY: 1789