AGRP - Agouti-related protein - human protein (Function)
 
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AGRP »  Agouti-related protein
 
Gene name:  AGRP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.  
6
  • UniProtKB
GO molecular function 
Neuropeptide hormone activitydefinition[GO:0005184]  
1
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • PINC
GO biological process 
Adult feeding behaviordefinition[GO:0008343] silver  
1
  • Ortholog Compara
Eating behaviordefinition[GO:0042755] silver  
1
  • Ortholog Compara
Feeding behaviordefinition[GO:0007631]  
1
  • PINC
Hormone-mediated signaling pathwaydefinition[GO:0009755] silver  
1
  • InterPro 2 GO
Maternal process involved in female pregnancydefinition[GO:0060135] silver  
1
  • Ortholog Compara
Neuropeptide signaling pathwaydefinition[GO:0007218]  
1
  • UniProtKB
Photoperiodismdefinition[GO:0009648] silver  
1
  • Ortholog Compara
Positive regulation of feeding behaviordefinition[GO:2000253] silver  
1
  • Ortholog Compara
Regulation of feeding behaviordefinition[GO:0060259]  
1
  • UniProtKB
Response to insulindefinition[GO:0032868] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Adipocytokine signaling pathway  hsa04920+181  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Agouti-related_peptide
GenomeRNAi: 181
PRO: PR:O00253