GPR31 - 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor - human protein (Function)
 
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GPR31 »  12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor  (12-HETER)
 
Protein also known as:  G-protein coupled receptor 31.
Gene name:  GPR31
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.  
1
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GPR31
GenomeRNAi: 2853
PRO: PR:O00270