HIP1 - Huntingtin-interacting protein 1 - human protein (Function)
 
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HIP1 »  Huntingtin-interacting protein 1  (HIP-1)
 
Protein also known as:  Huntingtin-interacting protein I (HIP-I).
Gene name:  HIP1
Family name: SLA2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 59 2
GENE REF ISO

Function

 show evidences
Overview 
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.  
8
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • IEAUniProtKB KW
Clathrin bindingdefinition[GO:0030276]  
1
  • IDAMGI
Phosphatidylinositol bindingdefinition[GO:0035091]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • TASPINC
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • IDAMGI
Apoptotic processdefinition[GO:0006915]  
1
  • IDAMGI
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • IDAUniProtKB
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Clathrin coat assemblydefinition[GO:0048268]  
2
  • IDAUniProtKB
  • IDAMGI
Endocytosisdefinition[GO:0006897] silver  
  • IEAOrtholog Compara
Positive regulation of receptor-mediated endocytosisdefinition[GO:0048260]  
2
  • IMPUniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • IDAMGI
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Huntington's disease  hsa05016+3092  
Note 
The affinity of the huntingtin protein-HIP1 interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Differentiation  definition   [KW-0221]
Endocytosis  definition   [KW-0254]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 3092
PRO: PR:O00291