CLIC1 - Chloride intracellular channel protein 1 - human protein (Function)
 
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Protein
Gene
References

 
CLIC1 »  Chloride intracellular channel protein 1
 
Protein also known as:  Regulatory nuclear chloride ion channel protein.
Gene name:  CLIC1
Family name: Chloride channel CLIC
Entry whose protein(s) existence is based on evidence at protein level
extend overview
7 64 1
GENE REF ISO

Function

 show evidences
Overview 
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.  
7
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the intracellular chloride channel (clic) family  1.A.12.1.2  
GO molecular function 
Chloride channel activitydefinition[GO:0005254]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
2
  • IPIBHF-UCL
  • IPIUniProtKB
Voltage-gated chloride channel activitydefinition[GO:0005247] silver  
  • IEAInterPro 2 GO
GO biological process 
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • IDAGOC
Chloride transportdefinition[GO:0006821]  
1
  • IDAMGI
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
  • IEAOrtholog Compara
Regulation of mitochondrial membrane potentialdefinition[GO:0051881] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLIC1
GenomeRNAi: 1192
PRO: PR:O00299