TNFRSF11B - Tumor necrosis factor receptor superfamily member 11B - human protein (Function)
 
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TNFRSF11B »  Tumor necrosis factor receptor superfamily member 11B
 
Protein also known as:  Osteoclastogenesis inhibitory factor.
Gene name:  TNFRSF11B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.  
3
  • UniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • PINC
Receptor activitydefinition[GO:0004872]  
1
  • PINC
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB KW
Extracellular matrix organizationdefinition[GO:0030198] silver  
1
  • Ortholog Compara
Negative regulation of bone resorptiondefinition[GO:0045779] silver  
1
  • Ortholog Compara
Negative regulation of odontogenesis of dentin-containing toothdefinition[GO:0042489] silver  
1
  • Ortholog Compara
Response to arsenic-containing substancedefinition[GO:0046685] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to estrogendefinition[GO:0043627] silver  
1
  • Ortholog Compara
Response to magnesium iondefinition[GO:0032026] silver  
1
  • Ortholog Compara
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165] silver  
1
  • InterPro 2 GO
Skeletal system developmentdefinition[GO:0001501]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+4982  
Osteoclast differentiation  hsa04380+4982  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Osteoprotegerin
GenomeRNAi: 4982
PRO: PR:O00300