CACNB4 - Voltage-dependent L-type calcium channel subunit beta-4 - human protein (Function)
 
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CACNB4 »  Voltage-dependent L-type calcium channel subunit beta-4  (CAB4)
 
Protein also known as:  Calcium channel voltage-dependent subunit beta 4.
Gene name:  CACNB4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 28 4
GENE REF ISO

Function

 show evidences
Overview 
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(2+) channel auxiliary subunit types 1-4 (cca-) family  8.A.22.1.4  
GO molecular function 
Isoform  Iso 1   Contributes to high voltage-gated calcium channel activitydefinition[GO:0008331]  
1
  • IDAUniProtKB
Isoform  Iso 2   Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
Contributes to voltage-gated calcium channel activitydefinition[GO:0005245]  
1
  • IDAUniProtKB
GO biological process 
Adult walking behaviordefinition[GO:0007628] silver  
  • IEAOrtholog Compara
Isoform  Iso 1   Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • IDAGOC
cAMP metabolic processdefinition[GO:0046058] silver  
  • IEAOrtholog Compara
Isoform  Iso 1   Cation transportdefinition[GO:0006812]  
1
  • IDAGOC
Cellular calcium ion homeostasisdefinition[GO:0006874] silver  
  • IEAOrtholog Compara
Detection of light stimulus involved in visual perceptiondefinition[GO:0050908] silver  
  • IEAOrtholog Compara
Isoform  Iso 1   Divalent inorganic cation transportdefinition[GO:0072511]  
1
  • IDAGOC
Gamma-aminobutyric acid secretiondefinition[GO:0014051] silver  
  • IEAOrtholog Compara
Gamma-aminobutyric acid signaling pathwaydefinition[GO:0007214] silver  
  • IEAOrtholog Compara
Isoform  Iso 1   Ion transmembrane transportdefinition[GO:0034220]  
1
  • IDAGOC
Isoform  Iso 1   Metal ion transportdefinition[GO:0030001]  
1
  • IDAGOC
Muscle fiber developmentdefinition[GO:0048747] silver  
  • IEAOrtholog Compara
Neuromuscular junction developmentdefinition[GO:0007528] silver  
  • IEAOrtholog Compara
Neuronal action potential propagationdefinition[GO:0019227] silver  
  • IEAOrtholog Compara
Peyer's patch developmentdefinition[GO:0048541] silver  
  • IEAOrtholog Compara
Isoform  Iso 1   Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • IDAGOC
Isoform  Iso 1   Regulation of transportdefinition[GO:0051049]  
1
  • IDAGOC
Regulation of voltage-gated calcium channel activitydefinition[GO:1901385]  
1
  • IMPUniProtKB
Spleen developmentdefinition[GO:0048536] silver  
  • IEAOrtholog Compara
Synaptic transmission, glutamatergicdefinition[GO:0035249] silver  
  • IEAOrtholog Compara
T cell receptor signaling pathwaydefinition[GO:0050852] silver  
  • IEAOrtholog Compara
Thymus developmentdefinition[GO:0048538] silver  
  • IEAOrtholog Compara
Isoform  Iso 1   Transmembrane transportdefinition[GO:0055085]  
1
  • IDAGOC
Transportdefinition[GO:0006810]  
2
  • IDAGOC
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+785  
Cardiac muscle contraction  hsa04260+785  
Dilated cardiomyopathy  hsa05414+785  
Hypertrophic cardiomyopathy (HCM)  hsa05410+785  
MAPK signaling pathway  hsa04010+785  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CACNB4
GenomeRNAi: 785
PRO: PR:O00305