ARNTL - Aryl hydrocarbon receptor nuclear translocator-like protein 1 - human protein (Function)
 
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Protein
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ARNTL »  Aryl hydrocarbon receptor nuclear translocator-like protein 1
 
Protein also known as:  Class E basic helix-loop-helix protein 5 (bHLHe5).
Gene name:  ARNTL
Entry whose protein(s) existence is based on evidence at protein level
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1 63 9
GENE REF ISO

Function

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Overview 
ARNTL-CLOCK heterodimers activate E-box element (5'-CACGTG-3') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Aryl hydrocarbon receptor bindingdefinition[GO:0017162]  
1
  • IPIBHF-UCL
bHLH transcription factor bindingdefinition[GO:0043425] silver  
  • IEAOrtholog Compara
Core promoter bindingdefinition[GO:0001047]  
  • ISSOrtholog Curator
DNA bindingdefinition[GO:0003677]  
1
  • IGIMGI
Hsp90 protein bindingdefinition[GO:0051879]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activitydefinition[GO:0000982]  
  • ISSOrtholog Curator
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001190] silver  
  • IEAOrtholog Compara
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
GO biological process 
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
Circadian rhythmdefinition[GO:0007623]  
1
  • TASPINC
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDABHF-UCL
  • IGIMGI
Protein import into nucleus, translocationdefinition[GO:0000060] silver  
  • IEAOrtholog Compara
Regulation of protein catabolic processdefinition[GO:0042176] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • ISSOrtholog Curator
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Circadian rhythm - mammal  hsa04710+406  
Dopaminergic synapse  hsa04728+406  
Herpes simplex infection  hsa05168+406  
According to Reactome, this protein belongs to the following pathway:
Circadian Clock  REACT_24941  
Note 
CLOCK-ARNTL double mutations within the PAS domains result in syngernistic desensitization to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1 and, disrupt circadian rhythmicity.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARNTL
GenomeRNAi: 406
PRO: PR:O00327