SLC28A1 - Sodium/nucleoside cotransporter 1 - human protein (Function)
 
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Protein
Gene
References

 
SLC28A1 »  Sodium/nucleoside cotransporter 1
 
Protein also known as:  Sodium-coupled nucleoside transporter 1.
Gene name:  SLC28A1
Entry whose protein(s) existence is based on evidence at protein level
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1 37 2
GENE REF ISO

Function

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Overview 
Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the concentrative nucleoside transporter (cnt) family  2.A.41.2.3  
GO molecular function 
Nucleoside bindingdefinition[GO:0001882] silver  
  • IEAInterPro 2 GO
Nucleoside transmembrane transporter activitydefinition[GO:0005337]  
1
  • TASPINC
Nucleoside:sodium symporter activitydefinition[GO:0005415] silver  
  • IEAInterPro 2 GO
GO biological process 
Nucleobase-containing compound metabolic processdefinition[GO:0006139]  
1
  • TASPINC
Nucleoside transmembrane transportdefinition[GO:1901642]  
1
  • TASGOC
Nucleoside transportdefinition[GO:0015858]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links