EEF2K - Eukaryotic elongation factor 2 kinase - human protein (Function)
 
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EEF2K »  Eukaryotic elongation factor 2 kinase   [ EC 2.7.11.20 ]  (eEF-2K)
 
Protein also known as:  Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase.
Gene name:  EEF2K
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Calcium ion bindingdefinition[GO:0005509] silver  
1
  • InterPro 2 GO
Calmodulin bindingdefinition[GO:0005516]  
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  • UniProtKB
Elongation factor-2 kinase activitydefinition[GO:0004686]  
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  • UniProtKB
Protein kinase activitydefinition[GO:0004672]  
1
  • PINC
Translation factor activity, RNA bindingdefinition[GO:0008135]  
1
  • PINC
GO biological process 
Protein autophosphorylationdefinition[GO:0046777]  
2
  • UniProtKB
Regulation of protein autophosphorylationdefinition[GO:0031952] silver  
1
  • Ortholog Compara
Translational elongationdefinition[GO:0006414]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.20: ATP + [elongation factor 2] ADP + [elongation factor 2] phosphate.  
2
  • UniProtKB
It is regulated in the following manner
Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
S6K1 signalling  REACT_6772  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EEF2K
PRO: PR:O00418
Chemistry
GuidetoPHARMACOLOGY: 2014