CCRL2 - C-C chemokine receptor-like 2 - human protein (Function)
 
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Protein
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References

 
CCRL2 »  C-C chemokine receptor-like 2
 
Protein also known as:  Putative MCP-1 chemokine receptor.
Gene name:  CCRL2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 19 2
GENE REF ISO

Function

 show evidences
Overview 
Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.  
  • CuratedUniProtKB
GO molecular function 
CCR chemokine receptor bindingdefinition[GO:0048020]  
1
  • IPIUniProtKB
Chemokine receptor activitydefinition[GO:0004950] silver  
  • IEAInterPro 2 GO
Chemokine receptor bindingdefinition[GO:0042379]  
1
  • IPIUniProtKB
GO biological process 
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • TASGOC
Chemotaxisdefinition[GO:0006935] silver  
  • IEAInterPro 2 GO
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • TASGOC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Inflammatory responsedefinition[GO:0006954]  
  • ISSOrtholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Note 
It was initially reported that CCRL2 responds functionally to CCL2, CCL5, CCL7, and CCL8 via intracellular calcium mobilization and transwell chemotaxis although no evidence for a direct ligand-receptor interaction was provided in this report. These results are now controversial, and other studies failed to confirm CCRL2 recognition and transwell chemotaxis of these chemokines or a series of other CC- and CXC-chemokines using CCRL2-transfected cells (PubMed15188357).  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CCRL2
GenomeRNAi: 9034
PRO: PR:O00421
Chemistry
GuidetoPHARMACOLOGY: 78