RTCA - RNA 3'-terminal phosphate cyclase - human protein (Function)
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RTCA »  RNA 3'-terminal phosphate cyclase   [ EC ]  (RNA cyclase)
Protein also known as:  RNA terminal phosphate cyclase domain-containing protein 1 (RTC domain-containing protein 1).
Gene name:  RTCA
Entry whose protein(s) existence is based on evidence at protein level
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Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
RNA bindingdefinition[GO:0003723]  
RNA-3'-phosphate cyclase activitydefinition[GO:0003963]  
  • IEAEC 2 GO
GO biological process 
RNA processingdefinition[GO:0006396] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP + RNA 3'-terminal-phosphate AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate.  
  • CuratedUniProtKB


Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 8634
PRO: PR:O00442