PIK3R2 - Phosphatidylinositol 3-kinase regulatory subunit beta - human protein (Function)
 
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PIK3R2 »  Phosphatidylinositol 3-kinase regulatory subunit beta  (PI3K regulatory subunit beta)
 
Protein also known as:  Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta (PI3-kinase subunit p85-beta).
Gene name:  PIK3R2
Family name: PI3K p85 subunit
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).  
3
  • UniProtKB
GO molecular function 
Contributes to 1-phosphatidylinositol-3-kinase activitydefinition[GO:0016303]  
1
  • Ortholog Curator
1-phosphatidylinositol-3-kinase regulator activitydefinition[GO:0046935]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
16
  • IntAct
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • Ortholog Curator
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • UniProtKB
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
1
  • UniProtKB
GO biological process 
Cellular glucose homeostasisdefinition[GO:0001678]  
1
  • Ortholog Curator
Cellular response to insulin stimulusdefinition[GO:0032869]  
1
  • Ortholog Curator
Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • RefGenome
Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
1
  • UniProtKB
Phosphatidylinositol phosphorylationdefinition[GO:0046854]  
1
  • RefGenome
Phosphatidylinositol-3-phosphate biosynthetic processdefinition[GO:0036092]  
1
  • Ortholog Curator
Positive regulation of glucose import in response to insulin stimulusdefinition[GO:2001275]  
1
  • Ortholog Curator
Positive regulation of transcription factor import into nucleusdefinition[GO:0042993]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • Ortholog Curator
Protein transportdefinition[GO:0015031]  
1
  • UniProtKB KW
Regulation of autophagydefinition[GO:0010506]  
1
  • UniProtKB
Regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043551]  
1
  • RefGenome
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+5296  
Amoebiasis  hsa05146+5296  
Apoptosis  hsa04210+5296  
B cell receptor signaling pathway  hsa04662+5296  
Bacterial invasion of epithelial cells  hsa05100+5296  
Carbohydrate digestion and absorption  hsa04973+5296  
Chagas disease (American trypanosomiasis)  hsa05142+5296  
Chemokine signaling pathway  hsa04062+5296  
Cholinergic synapse  hsa04725+5296  
Chronic myeloid leukemia  hsa05220+5296  
Colorectal cancer  hsa05210+5296  
Endometrial cancer  hsa05213+5296  
ErbB signaling pathway  hsa04012+5296  
Fc epsilon RI signaling pathway  hsa04664+5296  
Fc gamma R-mediated phagocytosis  hsa04666+5296  
Focal adhesion  hsa04510+5296  
Glioma  hsa05214+5296  
Hepatitis C  hsa05160+5296  
HTLV-I infection  hsa05166+5296  
Influenza A  hsa05164+5296  
Insulin signaling pathway  hsa04910+5296  
Jak-STAT signaling pathway  hsa04630+5296  
Leukocyte transendothelial migration  hsa04670+5296  
Measles  hsa05162+5296  
Melanoma  hsa05218+5296  
mTOR signaling pathway  hsa04150+5296  
Natural killer cell mediated cytotoxicity  hsa04650+5296  
Neurotrophin signaling pathway  hsa04722+5296  
Non-small cell lung cancer  hsa05223+5296  
Osteoclast differentiation  hsa04380+5296  
Pancreatic cancer  hsa05212+5296  
Pathways in cancer  hsa05200+5296  
Phosphatidylinositol signaling system  hsa04070+5296  
Progesterone-mediated oocyte maturation  hsa04914+5296  
Prostate cancer  hsa05215+5296  
Regulation of actin cytoskeleton  hsa04810+5296  
Renal cell carcinoma  hsa05211+5296  
Small cell lung cancer  hsa05222+5296  
T cell receptor signaling pathway  hsa04660+5296  
Toll-like receptor signaling pathway  hsa04620+5296  
Toxoplasmosis  hsa05145+5296  
Type II diabetes mellitus  hsa04930+5296  
VEGF signaling pathway  hsa04370+5296  
According to Reactome, this protein belongs to the following pathways:
CD28 dependent PI3K/Akt signaling  R-HSA-389357  
Constitutive Signaling by Aberrant PI3K in Cancer  R-HSA-2219530  
Costimulation by the CD28 family  R-HSA-388841  
DAP12 signaling  R-HSA-2424491  
Downstream signal transduction  R-HSA-186763  
Downstream TCR signaling  R-HSA-202424  
G alpha (12/13) signalling events  R-HSA-416482  
G alpha (q) signalling events  R-HSA-416476  
G beta:gamma signalling through PI3Kgamma  R-HSA-392451  
GPVI-mediated activation cascade  R-HSA-114604  
Interleukin receptor SHC signaling  R-HSA-912526  
Interleukin-3, 5 and GM-CSF signaling  R-HSA-512988  
Interleukin-7 signaling  R-HSA-1266695  
Nephrin interactions  R-HSA-373753  
PI3K Cascade  R-HSA-109704  
PI3K/AKT activation  R-HSA-198203  
PIP3 activates AKT signaling  R-HSA-1257604  
Regulation of signaling by CBL  R-HSA-912631  
Rho GTPase cycle  R-HSA-194840  
Role of LAT2/NTAL/LAB on calcium mobilization  R-HSA-2730905  
Role of phospholipids in phagocytosis  R-HSA-2029485  
Signaling by SCF-KIT  R-HSA-1433557  
Synthesis of PIPs at the plasma membrane  R-HSA-1660499  
Tie2 Signaling  R-HSA-210993  
VEGFA-VEGFR2 Pathway  R-HSA-4420097  
 
More information is available from:
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Stress response  definition   [KW-0346]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PIK3R2
GenomeRNAi: 5296
PRO: PR:O00459