PIK3R2 - Phosphatidylinositol 3-kinase regulatory subunit beta - human protein (Function)
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PIK3R2 »  Phosphatidylinositol 3-kinase regulatory subunit beta  (PI3K regulatory subunit beta)
Protein also known as:  Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta (PI3-kinase subunit p85-beta).
Gene name:  PIK3R2
Family name: PI3K p85 subunit
Entry whose protein(s) existence is based on evidence at protein level
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Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed23604317).  
  • UniProtKB
GO molecular function 
Contributes to 1-phosphatidylinositol-3-kinase activitydefinition[GO:0016303]  
  • Ortholog Curator
Phosphatidylinositol 3-kinase regulator activitydefinition[GO:0035014] silver  
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
  • IntAct
  • UniProtKB
Protein phosphatase bindingdefinition[GO:0019903]  
  • UniProtKB
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
  • UniProtKB
GO biological process 
Cellular glucose homeostasisdefinition[GO:0001678]  
  • Ortholog Curator
Cellular response to insulin stimulusdefinition[GO:0032869]  
  • Ortholog Curator
Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
  • UniProtKB
Phosphatidylinositol-3-phosphate biosynthetic processdefinition[GO:0036092]  
  • Ortholog Curator
Positive regulation of transcription factor import into nucleusdefinition[GO:0042993]  
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • Ortholog Curator
Regulation of autophagydefinition[GO:0010506]  
  • UniProtKB
Regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043551]  
  • InterPro 2 GO
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
  • Ortholog Curator
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+5296  
Amoebiasis  hsa05146+5296  
Apoptosis  hsa04210+5296  
B cell receptor signaling pathway  hsa04662+5296  
Bacterial invasion of epithelial cells  hsa05100+5296  
Carbohydrate digestion and absorption  hsa04973+5296  
Chagas disease (American trypanosomiasis)  hsa05142+5296  
Chemokine signaling pathway  hsa04062+5296  
Cholinergic synapse  hsa04725+5296  
Chronic myeloid leukemia  hsa05220+5296  
Colorectal cancer  hsa05210+5296  
Endometrial cancer  hsa05213+5296  
ErbB signaling pathway  hsa04012+5296  
Fc epsilon RI signaling pathway  hsa04664+5296  
Fc gamma R-mediated phagocytosis  hsa04666+5296  
Focal adhesion  hsa04510+5296  
Glioma  hsa05214+5296  
Hepatitis C  hsa05160+5296  
HTLV-I infection  hsa05166+5296  
Influenza A  hsa05164+5296  
Insulin signaling pathway  hsa04910+5296  
Jak-STAT signaling pathway  hsa04630+5296  
Leukocyte transendothelial migration  hsa04670+5296  
Measles  hsa05162+5296  
Melanoma  hsa05218+5296  
mTOR signaling pathway  hsa04150+5296  
Natural killer cell mediated cytotoxicity  hsa04650+5296  
Neurotrophin signaling pathway  hsa04722+5296  
Non-small cell lung cancer  hsa05223+5296  
Osteoclast differentiation  hsa04380+5296  
Pancreatic cancer  hsa05212+5296  
Pathways in cancer  hsa05200+5296  
Phosphatidylinositol signaling system  hsa04070+5296  
Progesterone-mediated oocyte maturation  hsa04914+5296  
Prostate cancer  hsa05215+5296  
Regulation of actin cytoskeleton  hsa04810+5296  
Renal cell carcinoma  hsa05211+5296  
Small cell lung cancer  hsa05222+5296  
T cell receptor signaling pathway  hsa04660+5296  
Toll-like receptor signaling pathway  hsa04620+5296  
Toxoplasmosis  hsa05145+5296  
Type II diabetes mellitus  hsa04930+5296  
VEGF signaling pathway  hsa04370+5296  
According to Reactome, this protein belongs to the following pathways:
CD28 dependent PI3K/Akt signaling  REACT_19358  
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
Costimulation by the CD28 family  REACT_19344  
DAP12 signaling  REACT_147814  
Downstream signal transduction  REACT_17025  
Downstream TCR signaling  REACT_12555  
G alpha (12/13) signalling events  REACT_18407  
G alpha (q) signalling events  REACT_18283  
G beta:gamma signalling through PI3Kgamma  REACT_19290  
GPVI-mediated activation cascade  REACT_1695  
Interleukin receptor SHC signaling  REACT_23891  
Interleukin-3, 5 and GM-CSF signaling  REACT_23837  
Interleukin-7 signaling  REACT_115529  
Nephrin interactions  REACT_23832  
PI3K Cascade  REACT_976  
PI3K/AKT activation  REACT_12464  
PIP3 activates AKT signaling  REACT_75829  
Regulation of signaling by CBL  REACT_23787  
Rho GTPase cycle  REACT_11051  
Role of LAT2/NTAL/LAB on calcium mobilization  REACT_163769  
Role of phospholipids in phagocytosis  REACT_160158  
Signaling by SCF-KIT  REACT_111040  
Synthesis of PIPs at the plasma membrane  REACT_121025  
Tie2 Signaling  REACT_12621  
VEGFA-VEGFR2 Pathway  REACT_228166  
More information is available from:


Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: PIK3R2
GenomeRNAi: 5296
PRO: PR:O00459