PIK3R2 - Phosphatidylinositol 3-kinase regulatory subunit beta - human protein (Function)
 
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PIK3R2 »  Phosphatidylinositol 3-kinase regulatory subunit beta  (PI3K regulatory subunit beta)
 
Protein also known as:  Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta (PI3-kinase subunit p85-beta).
Gene name:  PIK3R2
Family name: PI3K p85 subunit
Entry whose protein(s) existence is based on evidence at protein level
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1 58 1
GENE REF ISO

Function

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Overview 
Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.  
  • CuratedUniProtKB
GO molecular function 
Contributes to 1-phosphatidylinositol-3-kinase activitydefinition[GO:0016303]  
  • ISSOrtholog Curator
Phosphatidylinositol 3-kinase regulator activitydefinition[GO:0035014] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
1
  • IPIUniProtKB
GO biological process 
Phosphatidylinositol-3-phosphate biosynthetic processdefinition[GO:0036092]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+5296  
Amoebiasis  hsa05146+5296  
Apoptosis  hsa04210+5296  
B cell receptor signaling pathway  hsa04662+5296  
Bacterial invasion of epithelial cells  hsa05100+5296  
Carbohydrate digestion and absorption  hsa04973+5296  
Chagas disease (American trypanosomiasis)  hsa05142+5296  
Chemokine signaling pathway  hsa04062+5296  
Cholinergic synapse  hsa04725+5296  
Chronic myeloid leukemia  hsa05220+5296  
Colorectal cancer  hsa05210+5296  
Endometrial cancer  hsa05213+5296  
ErbB signaling pathway  hsa04012+5296  
Fc epsilon RI signaling pathway  hsa04664+5296  
Fc gamma R-mediated phagocytosis  hsa04666+5296  
Focal adhesion  hsa04510+5296  
Glioma  hsa05214+5296  
Hepatitis C  hsa05160+5296  
HTLV-I infection  hsa05166+5296  
Influenza A  hsa05164+5296  
Insulin signaling pathway  hsa04910+5296  
Jak-STAT signaling pathway  hsa04630+5296  
Leukocyte transendothelial migration  hsa04670+5296  
Measles  hsa05162+5296  
Melanoma  hsa05218+5296  
mTOR signaling pathway  hsa04150+5296  
Natural killer cell mediated cytotoxicity  hsa04650+5296  
Neurotrophin signaling pathway  hsa04722+5296  
Non-small cell lung cancer  hsa05223+5296  
Osteoclast differentiation  hsa04380+5296  
Pancreatic cancer  hsa05212+5296  
Pathways in cancer  hsa05200+5296  
Phosphatidylinositol signaling system  hsa04070+5296  
Progesterone-mediated oocyte maturation  hsa04914+5296  
Prostate cancer  hsa05215+5296  
Regulation of actin cytoskeleton  hsa04810+5296  
Renal cell carcinoma  hsa05211+5296  
Small cell lung cancer  hsa05222+5296  
T cell receptor signaling pathway  hsa04660+5296  
Toll-like receptor signaling pathway  hsa04620+5296  
Toxoplasmosis  hsa05145+5296  
Type II diabetes mellitus  hsa04930+5296  
VEGF signaling pathway  hsa04370+5296  
According to Reactome, this protein belongs to the following pathways:
Cell-Cell communication  REACT_111155  
Disease  REACT_116125  
Hemostasis  REACT_604  
Immune System  REACT_6900  
Metabolism  REACT_111217  
Signal Transduction  REACT_111102  
 
More information is available from:
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PIK3R2
GenomeRNAi: 5296
PRO: PR:O00459