STK25 - Serine/threonine-protein kinase 25 - human protein (Function)
 
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STK25 »  Serine/threonine-protein kinase 25   [ EC 2.7.11.1 ]
 
Protein also known as:  Sterile 20/oxidant stress-response kinase 1 (SOK-1).
Gene name:  STK25
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
11
  • IntAct
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Protein kinase activitydefinition[GO:0004672]  
1
  • PINC
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702]  
1
  • RefGenome
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • RefGenome
Establishment of Golgi localizationdefinition[GO:0051683]  
1
  • UniProtKB
Establishment or maintenance of cell polaritydefinition[GO:0007163] silver  
1
  • Ortholog Compara
Golgi localizationdefinition[GO:0051645]  
1
  • UniProtKB
Golgi reassemblydefinition[GO:0090168]  
1
  • UniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • RefGenome
Intrinsic apoptotic signaling pathway in response to hydrogen peroxidedefinition[GO:0036481]  
1
  • UniProtKB
Positive regulation of axonogenesisdefinition[GO:0050772] silver  
1
  • Ortholog Compara
Positive regulation of stress-activated MAPK cascadedefinition[GO:0032874]  
1
  • UniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Regulation of cell differentiationdefinition[GO:0045595]  
1
  • RefGenome
Response to hydrogen peroxidedefinition[GO:0042542]  
1
  • UniProtKB
Response to oxidative stressdefinition[GO:0006979]  
1
  • PINC
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Signal transduction by protein phosphorylationdefinition[GO:0023014]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-174, possibly as a consequence of stabilization of dimer formation. The C-terminal non-catalytic region inhibits the kinase activity.  
2
  • UniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: STK25
GenomeRNAi: 10494
PRO: PR:O00506
Chemistry
GuidetoPHARMACOLOGY: 2218