USP9Y - Probable ubiquitin carboxyl-terminal hydrolase FAF-Y - human protein (Function)
 
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USP9Y »  Probable ubiquitin carboxyl-terminal hydrolase FAF-Y   [ EC 3.4.19.12 ]
 
Protein also known as:  Ubiquitin-specific-processing protease FAF-Y.
Gene name:  USP9Y
Family name: Peptidase C19
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiqitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity).  
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  • UniProtKB
GO molecular function 
Co-SMAD bindingdefinition[GO:0070410]  
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  • Ortholog Curator
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
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  • RefGenome
Cysteine-type peptidase activitydefinition[GO:0008234]  
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  • PINC
Ubiquitin thiolesterase activitydefinition[GO:0004221]  
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  • RefGenome
Ubiquitin-specific protease activitydefinition[GO:0004843]  
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  • PINC
GO biological process 
BMP signaling pathwaydefinition[GO:0030509]  
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  • Ortholog Curator
Cell migrationdefinition[GO:0016477]  
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  • RefGenome
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161]  
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  • RefGenome
Protein deubiquitinationdefinition[GO:0016579]  
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  • Ortholog Curator
  • RefGenome
Regulation of proteasomal protein catabolic processdefinition[GO:0061136]  
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  • RefGenome
Spermatogenesisdefinition[GO:0007283]  
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  • PINC
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
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  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
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  • UniProtKB
 
More information is available from:
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: USP9Y
GenomeRNAi: 8287
PRO: PR:O00507