FAAH - Fatty-acid amide hydrolase 1 - human protein (Function)
 
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Protein
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FAAH »  Fatty-acid amide hydrolase 1   [ EC 3.5.1.99 ]
 
Protein also known as:  Anandamide amidohydrolase 1.
Gene name:  FAAH
Family name: Amidase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.  
1
  • CuratedUniProtKB
GO molecular function 
Acylglycerol lipase activitydefinition[GO:0047372] silver  
  • IEAOrtholog Compara
Carbon-nitrogen ligase activity, with glutamine as amido-N-donordefinition[GO:0016884] silver  
  • IEAInterPro 2 GO
Fatty acid amide hydrolase activitydefinition[GO:0017064]  
1
  • IDAUniProtKB
GO biological process 
Fatty acid catabolic processdefinition[GO:0009062]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
Anandamide + H(2)O arachidonic acid + ethanolamine.  
  • CuratedUniProtKB
Oleamide + H(2)O oleic acid + NH(3).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by O-aryl carbamates and alpha-keto heterocytes.  
1
  • CuratedUniProtKB
Pathways 
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 2166
PRO: PR:O00519
Chemistry
GuidetoPHARMACOLOGY: 1400