CACNA1A - Voltage-dependent P/Q-type calcium channel subunit alpha-1A - human protein (Function)
 
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CACNA1A »  Voltage-dependent P/Q-type calcium channel subunit alpha-1A
 
Protein also known as:  Calcium channel, L type, alpha-1 polypeptide isoform 4.
Gene name:  CACNA1A
Entry whose protein(s) existence is based on evidence at protein level
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1 171 8
GENE REF ISO

Function

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Overview 
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.11.27  
GO molecular function 
High voltage-gated calcium channel activitydefinition[GO:0008331] silver  
  • IBARefGenome
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Syntaxin bindingdefinition[GO:0019905]  
1
  • IDAUniProtKB
Voltage-gated calcium channel activitydefinition[GO:0005245]  
2
  • IDAUniProtKB
  • ISSOrtholog Curator
GO biological process 
Adult walking behaviordefinition[GO:0007628] silver  
  • IEAOrtholog Compara
Behavioral response to paindefinition[GO:0048266] silver  
  • IEAOrtholog Compara
Calcium ion importdefinition[GO:0070509] silver  
  • IBARefGenome
Calcium ion-dependent exocytosisdefinition[GO:0017156] silver  
  • IEAOrtholog Compara
Calcium ion-dependent exocytosis of neurotransmitterdefinition[GO:0048791] silver  
  • IEAOrtholog Compara
Cell deathdefinition[GO:0008219]  
1
  • IDAUniProtKB
Cell growthdefinition[GO:0016049] silver  
  • IEAOrtholog Compara
Cellular chloride ion homeostasisdefinition[GO:0030644] silver  
  • IEAOrtholog Compara
Cerebellar molecular layer developmentdefinition[GO:0021679] silver  
  • IEAOrtholog Compara
Cerebellar Purkinje cell differentiationdefinition[GO:0021702] silver  
  • IEAOrtholog Compara
Cerebellum maturationdefinition[GO:0021590] silver  
  • IEAOrtholog Compara
Dendrite morphogenesisdefinition[GO:0048813] silver  
  • IEAOrtholog Compara
Gamma-aminobutyric acid secretiondefinition[GO:0014051] silver  
  • IEAOrtholog Compara
Gamma-aminobutyric acid signaling pathwaydefinition[GO:0007214] silver  
  • IEAOrtholog Compara
Glucose metabolic processdefinition[GO:0006006] silver  
  • IEAOrtholog Compara
Hormone metabolic processdefinition[GO:0042445] silver  
  • IEAOrtholog Compara
Membrane depolarization during action potentialdefinition[GO:0086010] silver  
  • IBARefGenome
Musculoskeletal movement, spinal reflex actiondefinition[GO:0050883] silver  
  • IEAOrtholog Compara
Negative regulation of hormone biosynthetic processdefinition[GO:0032353] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Neuromuscular process controlling balancedefinition[GO:0050885] silver  
  • IEAOrtholog Compara
Neuromuscular synaptic transmissiondefinition[GO:0007274] silver  
  • IEAOrtholog Compara
Neurotransmitter metabolic processdefinition[GO:0042133] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Receptor clusteringdefinition[GO:0043113] silver  
  • IEAOrtholog Compara
Regulation of acetylcholine secretion, neurotransmissiondefinition[GO:0014056] silver  
  • IEAOrtholog Compara
Regulation of axonogenesisdefinition[GO:0050770] silver  
  • IEAOrtholog Compara
Regulation of calcium ion-dependent exocytosisdefinition[GO:0017158] silver  
  • IEAOrtholog Compara
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Rhythmic synaptic transmissiondefinition[GO:0060024] silver  
  • IEAOrtholog Compara
Spinal cord motor neuron differentiationdefinition[GO:0021522] silver  
  • IEAOrtholog Compara
Sulfur amino acid metabolic processdefinition[GO:0000096] silver  
  • IEAOrtholog Compara
Synapse assemblydefinition[GO:0007416] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268] silver  
  • IBARefGenome
Synaptic transmission, glutamatergicdefinition[GO:0035249] silver  
  • IEAOrtholog Compara
Transmission of nerve impulsedefinition[GO:0019226] silver  
  • IEAOrtholog Compara
Vestibular nucleus developmentdefinition[GO:0021750] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+773  
Cholinergic synapse  hsa04725+773  
Dopaminergic synapse  hsa04728+773  
GABAergic synapse  hsa04727+773  
Glutamatergic synapse  hsa04724+773  
Long-term depression  hsa04730+773  
MAPK signaling pathway  hsa04010+773  
Synaptic vesicle cycle  hsa04721+773  
Taste transduction  hsa04742+773  
Type II diabetes mellitus  hsa04930+773  
According to Reactome, this protein belongs to the following pathways:
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels  REACT_13606  
Regulation of insulin secretion  REACT_18325  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cav2.1
GenomeRNAi: 773
PRO: PR:O00555
Chemistry
GuidetoPHARMACOLOGY: 532