ACKR2 - Atypical chemokine receptor 2 - human protein (Function)
 
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ACKR2 »  Atypical chemokine receptor 2
 
Protein also known as:  Chemokine-binding protein D6.
Gene name:  ACKR2
Entry whose protein(s) existence is based on evidence at protein level
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1 45 1
GENE REF ISO

Function

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Overview 
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.  
2
  • CuratedUniProtKB
GO molecular function 
C-C chemokine bindingdefinition[GO:0019957] silver  
  • IEAOrtholog Compara
C-C chemokine receptor activitydefinition[GO:0016493] silver  
  • IEAOrtholog Compara
C-X-C chemokine receptor activitydefinition[GO:0016494] silver  
  • IEAInterPro 2 GO
Chemokine receptor activitydefinition[GO:0004950]  
1
  • TASPINC
Scavenger receptor activitydefinition[GO:0005044]  
1
  • IMPUniProtKB
GO biological process 
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • TASGOC
  • IEAInterPro 2 GO
  • IEAOrtholog Compara
Chemotaxisdefinition[GO:0006935] silver  
  • IEAInterPro 2 GO
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Inflammatory responsedefinition[GO:0006954]  
  • IEAUniProtKB KW
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Neutrophil activationdefinition[GO:0042119] silver  
  • IEAInterPro 2 GO
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • IMPGOC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Chemokine receptors bind chemokines  REACT_15344  
 

Keywords

Biological process 
Inflammatory response  definition   [KW-0395]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CCBP2
GenomeRNAi: 1238
PRO: PR:O00590