GABRP - Gamma-aminobutyric acid receptor subunit pi - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
GABRP »  Gamma-aminobutyric acid receptor subunit pi
 
Protein also known as:  GABA(A) receptor subunit pi.
Gene name:  GABRP
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 20 1
GENE REF ISO

Function

 show evidences
Overview 
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.  
  • CuratedUniProtKB
GO molecular function 
Chloride channel activitydefinition[GO:0005254]  
  • IEAUniProtKB KW
Extracellular ligand-gated ion channel activitydefinition[GO:0005230] silver  
  • IEAInterPro 2 GO
GABA-A receptor activitydefinition[GO:0004890] silver  
  • IEAInterPro 2 GO
GO biological process 
Signal transductiondefinition[GO:0007165]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
GABAergic synapse  hsa04727+2568  
Neuroactive ligand-receptor interaction  hsa04080+2568  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GABRP
GenomeRNAi: 2568
PRO: PR:O00591
Chemistry
GuidetoPHARMACOLOGY: 419