PODXL - Podocalyxin - human protein (Function)
 
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Protein
Gene
References

 
PODXL »  Podocalyxin
 
Protein also known as:  Podocalyxin-like protein 1 (PC).
Gene name:  PODXL
Family name: Podocalyxin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 72 2
GENE REF ISO

Function

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Overview 
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.  
3
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB KW
Cell migrationdefinition[GO:0016477]  
1
  • Ortholog Curator
Epithelial tube formationdefinition[GO:0072175]  
1
  • Ortholog Curator
Glomerular visceral epithelial cell developmentdefinition[GO:0072015]  
1
  • Ortholog Curator
Leukocyte migrationdefinition[GO:0050900] silver  
1
  • Ortholog Compara
Negative regulation of cell adhesiondefinition[GO:0007162]  
1
  • Ortholog Curator
Negative regulation of cell-cell adhesiondefinition[GO:0022408]  
1
  • Ortholog Curator
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • UniProtKB
Positive regulation of cell-cell adhesion mediated by integrindefinition[GO:0033634]  
1
  • UniProtKB
Regulation of microvillus assemblydefinition[GO:0032534]  
1
  • Ortholog Curator
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PODXL
GenomeRNAi: 5420
PRO: PR:O00592