CLDN4 - Claudin-4 - human protein (Function)
 
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Protein
Gene
References

 
CLDN4 »  Claudin-4
 
Protein also known as:  Williams-Beuren syndrome chromosomal region 8 protein.
Gene name:  CLDN4
Family name: Claudin
Entry whose protein(s) existence is based on evidence at protein level
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1 81 1
GENE REF ISO

Function

 show evidences
Overview 
Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the claudin tight junction (claudin) family  1.H.1.1.6  
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
  • ISSOrtholog Curator
Structural molecule activitydefinition[GO:0005198] silver  
  • IEAInterPro 2 GO
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • TASPINC
GO biological process 
Calcium-independent cell-cell adhesiondefinition[GO:0016338]  
  • ISSOrtholog Curator
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
Response to progesteronedefinition[GO:0032570] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell adhesion molecules (CAMs)  hsa04514+1364  
Hepatitis C  hsa05160+1364  
Leukocyte transendothelial migration  hsa04670+1364  
Tight junction  hsa04530+1364  
According to Reactome, this protein belongs to the following pathway:
Cell-Cell communication  REACT_111155  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLDN4
GenomeRNAi: 1364
PRO: PR:O14493