PPAP2A - Lipid phosphate phosphohydrolase 1 - human protein (Function)
 
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Protein
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References

 
PPAP2A »  Lipid phosphate phosphohydrolase 1   [ EC 3.1.3.4 ]
 
Protein also known as:  Phosphatidate phosphohydrolase type 2a.
Gene name:  PPAP2A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 2
GENE REF ISO

Function

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Overview 
Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.  
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  • CuratedUniProtKB
GO molecular function 
Phosphatidate phosphatase activitydefinition[GO:0008195]  
2
  • NASUniProtKB
GO biological process 
Androgen receptor signaling pathwaydefinition[GO:0030521]  
1
  • NASUniProtKB
Germ cell migrationdefinition[GO:0008354]  
1
  • TASPINC
Intracellular steroid hormone receptor signaling pathwaydefinition[GO:0030518]  
1
  • TASUniProtKB
Lipid metabolic processdefinition[GO:0006629]  
1
  • NASPINC
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • NASUniProtKB
Phospholipid dephosphorylationdefinition[GO:0046839]  
1
  • TASUniProtKB
Protein dephosphorylationdefinition[GO:0006470] silver  
  • IEAOrtholog Compara
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205]  
1
  • TASUniProtKB
Regulation of lipid metabolic processdefinition[GO:0019216]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.4: A 1,2-diacylglycerol 3-phosphate + H(2)O a 1,2-diacyl-sn-glycerol + phosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Ether lipid metabolism  hsa00565+8611  
Fat digestion and absorption  hsa04975+8611  
Fc gamma R-mediated phagocytosis  hsa04666+8611  
Glycerolipid metabolism  hsa00561+8611  
Glycerophospholipid metabolism  hsa00564+8611  
Metabolic pathways  hsa01100+8611  
Sphingolipid metabolism  hsa00600+8611  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
Caution 
PubMed9305923 states that this phosphatase does not hydrolyze sphingosine 1-phosphate while PubMed9705349 states that it does.  
2
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPAP2A
GenomeRNAi: 8611
PRO: PR:O14494