ARID1A - AT-rich interactive domain-containing protein 1A - human protein (Function)
 
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ARID1A »  AT-rich interactive domain-containing protein 1A  (ARID domain-containing protein 1A)
 
Protein also known as:  SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1.
Gene name:  ARID1A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 94 3
GENE REF ISO

Function

 show evidences
Overview 
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
2
  • IDAMGI
  • NASUniProtKB
Ligand-dependent nuclear receptor bindingdefinition[GO:0016922]  
1
  • IPIBHF-UCL
Nucleosome bindingdefinition[GO:0031491] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIBHF-UCL
Transcription coactivator activitydefinition[GO:0003713]  
1
  • NASBHF-UCL
GO biological process 
Androgen receptor signaling pathwaydefinition[GO:0030521]  
1
  • IDAUniProtKB
ATP-dependent chromatin remodelingdefinition[GO:0043044] silver  
  • IEAOrtholog Compara
Cardiac chamber developmentdefinition[GO:0003205] silver  
  • IEAOrtholog Compara
Chromatin remodelingdefinition[GO:0006338]  
1
  • IDABHF-UCL
Chromatin-mediated maintenance of transcriptiondefinition[GO:0048096]  
1
  • TASUniProtKB
Forebrain developmentdefinition[GO:0030900] silver  
  • IEAOrtholog Compara
Glucocorticoid receptor signaling pathwaydefinition[GO:0042921]  
1
  • IDAUniProtKB
Intracellular estrogen receptor signaling pathwaydefinition[GO:0030520]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Nucleosome disassemblydefinition[GO:0006337]  
1
  • IDABHF-UCL
Nucleosome mobilizationdefinition[GO:0042766]  
1
  • TASUniProtKB
Optic cup formation involved in camera-type eye developmentdefinition[GO:0003408] silver  
  • IEAOrtholog Compara
Placenta blood vessel developmentdefinition[GO:0060674] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • NASBHF-UCL
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARID1A
GenomeRNAi: 8289
PRO: PR:O14497