BHLHE40 - Class E basic helix-loop-helix protein 40 - human protein (Function)
 
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BHLHE40 »  Class E basic helix-loop-helix protein 40  (bHLHe40)
 
Protein also known as:  Differentially expressed in chondrocytes protein 1 (DEC1).
Gene name:  BHLHE40
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 43 1
GENE REF ISO

Function

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Overview 
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.  
6
  • CuratedUniProtKB
GO molecular function 
bHLH transcription factor bindingdefinition[GO:0043425]  
2
  • IPIBHF-UCL
E-box bindingdefinition[GO:0070888]  
6
  • IDABHF-UCL
MRF bindingdefinition[GO:0043426]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
3
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
  • ISSOrtholog Curator
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
3
  • IDABHF-UCL
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
  • ISSOrtholog Curator
RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001191]  
2
  • IDABHF-UCL
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • NASUniProtKB
Transcription corepressor activitydefinition[GO:0003714]  
1
  • IDAUniProtKB
GO biological process 
Circadian regulation of gene expressiondefinition[GO:0032922]  
1
  • IDABHF-UCL
Entrainment of circadian clock by photoperioddefinition[GO:0043153]  
1
  • ISSBHF-UCL
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • IDABHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
4
  • IDABHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IDAGOC
  • ISSOrtholog Curator
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Circadian rhythm - mammal  hsa04710+8553  
According to Reactome, this protein belongs to the following pathway:
BMAL1:CLOCK,NPAS2 activates circadian gene expression  REACT_111118  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BHLHB2
GenomeRNAi: 8553
PRO: PR:O14503