SOCS7 - Suppressor of cytokine signaling 7 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
SOCS7 »  Suppressor of cytokine signaling 7  (SOCS-7)
 
Protein also known as:  Nck, Ash and phospholipase C gamma-binding protein.
Gene name:  SOCS7
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 20 2
GENE REF ISO

Function

 show evidences
Overview 
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).  
1
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein kinase inhibitor activitydefinition[GO:0004860]  
1
  • RefGenome
SH3 domain bindingdefinition[GO:0017124]  
1
  • UniProtKB
GO biological process 
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • RefGenome
Fat cell differentiationdefinition[GO:0045444] silver  
1
  • Ortholog Compara
Insulin receptor signaling pathwaydefinition[GO:0008286] silver  
1
  • Ortholog Compara
Intracellular signal transductiondefinition[GO:0035556] silver  
1
  • InterPro 2 GO
Negative regulation of JAK-STAT cascadedefinition[GO:0046426]  
1
  • RefGenome
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • RefGenome
Protein ubiquitinationdefinition[GO:0016567]  
1
  • UniPathway
Regulation of growthdefinition[GO:0040008]  
1
  • UniProtKB KW
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathway:
Jak-STAT signaling pathway  hsa04630+30837  
 

Keywords

Biological process 
Growth regulation  definition   [KW-0341]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Signal transduction inhibitor  definition   [KW-0734]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SOCS7
GenomeRNAi: 30837
PRO: PR:O14512