SOCS6 - Suppressor of cytokine signaling 6 - human protein (Function)
 
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SOCS6 »  Suppressor of cytokine signaling 6  (SOCS-6)
 
Protein also known as:  Suppressor of cytokine signaling 4 (SOCS-4).
Gene name:  SOCS6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 38 1
GENE REF ISO

Function

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Overview 
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.  
2
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein kinase inhibitor activitydefinition[GO:0004860]  
1
  • RefGenome
GO biological process 
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • RefGenome
Defense responsedefinition[GO:0006952]  
1
  • PINC
JAK-STAT cascadedefinition[GO:0007259]  
1
  • PINC
Negative regulation of JAK-STAT cascadedefinition[GO:0046426]  
1
  • RefGenome
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • RefGenome
Negative regulation of T cell activationdefinition[GO:0050868] silver  
1
  • Ortholog Compara
Proteasomal protein catabolic processdefinition[GO:0010498]  
1
  • MGI
Protein ubiquitinationdefinition[GO:0016567]  
1
  • UniPathway
Regulation of growthdefinition[GO:0040008] silver  
1
  • Ortholog Compara
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
1
  • UniProtKB
According to Reactome, this protein belongs to the following pathway:
Regulation of KIT signaling  REACT_111225  
 

Keywords

Biological process 
Growth regulation  definition   [KW-0341]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Signal transduction inhibitor  definition   [KW-0734]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SOCS6
GenomeRNAi: 9306
PRO: PR:O14544