CIT - Citron Rho-interacting kinase - human protein (Function)
 
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CIT »  Citron Rho-interacting kinase   [ EC 2.7.11.1 ]  (CRIK)
 
Protein also known as:  Serine/threonine-protein kinase 21.
Gene name:  CIT
Entry whose protein(s) existence is based on evidence at protein level
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1 56 4
GENE REF ISO

Function

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Overview 
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • ISSUniProtKB
Rho GTPase bindingdefinition[GO:0017048] silver  
  • IEAOrtholog Compara
SH3 domain bindingdefinition[GO:0017124]  
  • IEAUniProtKB KW
Small GTPase regulator activitydefinition[GO:0005083] silver  
  • IEAInterPro 2 GO
GO biological process 
Cytokinesisdefinition[GO:0000910]  
1
  • IMPUniProtKB
Dendrite developmentdefinition[GO:0016358] silver  
  • IEAOrtholog Compara
G2/M transition of mitotic cell cycledefinition[GO:0000086] silver  
  • IEAOrtholog Compara
Generation of neuronsdefinition[GO:0048699]  
1
  • ISSUniProtKB
Golgi organizationdefinition[GO:0007030] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Metaphase/anaphase transition of mitotic cell cycledefinition[GO:0007091] silver  
  • IEAOrtholog Compara
Mitosisdefinition[GO:0007067]  
1
  • ISSUniProtKB
Mitotic sister chromatid segregationdefinition[GO:0000070] silver  
  • IEAOrtholog Compara
Negative regulation of dendrite morphogenesisdefinition[GO:0050774] silver  
  • IEAOrtholog Compara
Regulation of actin polymerization or depolymerizationdefinition[GO:0008064] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Differentiation  definition   [KW-0221]
Mitosis  definition   [KW-0498]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CIT_(gene)
GenomeRNAi: 11113
PRO: PR:O14578
Chemistry
GuidetoPHARMACOLOGY: 1509