KCNK3 - Potassium channel subfamily K member 3 - human protein (Function)
 
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KCNK3 »  Potassium channel subfamily K member 3
 
Protein also known as:  Acid-sensitive potassium channel protein TASK-1.
Gene name:  KCNK3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
PH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.9.2  
GO molecular function 
Ion channel activitydefinition[GO:0005216]  
1
  • UniProtKB
Open rectifier potassium channel activitydefinition[GO:0005252] silver  
1
  • Ortholog Compara
Potassium channel activitydefinition[GO:0005267]  
1
  • PINC
Potassium ion leak channel activitydefinition[GO:0022841]  
1
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
1
  • Ortholog Compara
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
S100 protein bindingdefinition[GO:0044548]  
1
  • UniProtKB
GO biological process 
Activation of mitophagy in response to mitochondrial depolarizationdefinition[GO:0098779]  
1
  • ParkinsonsUK-UCL
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
1
  • Ortholog Compara
Cellular response to zinc iondefinition[GO:0071294] silver  
1
  • Ortholog Compara
Cochlea developmentdefinition[GO:0090102] silver  
1
  • Ortholog Compara
Ion transmembrane transportdefinition[GO:0034220]  
1
  • UniProtKB
Negative regulation of cytosolic calcium ion concentrationdefinition[GO:0051481] silver  
1
  • Ortholog Compara
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • RefGenome
Potassium ion transportdefinition[GO:0006813]  
1
  • PINC
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Stabilization of membrane potentialdefinition[GO:0030322]  
1
  • RefGenome
Pathways 
According to Reactome, this protein belongs to the following pathway:
TWIK-releated acid-sensitive K+ channel (TASK)  REACT_75899  
Note 
Inhibited by external acidification. Activated by halothane and isoflurane.  
1
  • UniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNK3
GenomeRNAi: 3777
PRO: PR:O14649
Chemistry
GuidetoPHARMACOLOGY: 515