KCNK3 - Potassium channel subfamily K member 3 - human protein (Function)
 
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KCNK3 »  Potassium channel subfamily K member 3
 
Protein also known as:  Acid-sensitive potassium channel protein TASK-1.
Gene name:  KCNK3
Entry whose protein(s) existence is based on evidence at protein level
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1 42 1
GENE REF ISO

Function

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Overview 
PH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.9.2  
GO molecular function 
Ion channel activitydefinition[GO:0005216]  
1
  • IMPUniProtKB
Open rectifier potassium channel activitydefinition[GO:0005252] silver  
  • IEAOrtholog Compara
Potassium channel activitydefinition[GO:0005267]  
1
  • TASPINC
Potassium ion leak channel activitydefinition[GO:0022841]  
1
  • IDAUniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
  • IEAOrtholog Compara
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
S100 protein bindingdefinition[GO:0044548]  
1
  • IPIUniProtKB
GO biological process 
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
  • IEAOrtholog Compara
Cellular response to zinc iondefinition[GO:0071294] silver  
  • IEAOrtholog Compara
Cochlea developmentdefinition[GO:0090102] silver  
  • IEAOrtholog Compara
Ion transmembrane transportdefinition[GO:0034220]  
1
  • IMPUniProtKB
Negative regulation of cytosolic calcium ion concentrationdefinition[GO:0051481] silver  
  • IEAOrtholog Compara
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
Note 
Inhibited by external acidification. Activated by halothane and isoflurane.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNK3
GenomeRNAi: 3777
PRO: PR:O14649
Chemistry
GuidetoPHARMACOLOGY: 515