TOR1B - Torsin-1B - human protein (Function)
 
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Gene
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TOR1B »  Torsin-1B
 
Protein also known as:  Torsin family 1 member B.
Gene name:  TOR1B
Family name: ClpA/ClpB » Torsin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues.  
3
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
ATPase activitydefinition[GO:0016887]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
GO biological process 
Chaperone mediated protein folding requiring cofactordefinition[GO:0051085] silver  
1
  • InterPro 2 GO
Endoplasmic reticulum organizationdefinition[GO:0007029]  
1
  • UniProtKB
Nuclear membrane organizationdefinition[GO:0071763] silver  
1
  • Ortholog Compara
Protein homooligomerizationdefinition[GO:0051260]  
1
  • MGI
Response to unfolded proteindefinition[GO:0006986]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.-: ATP + H(2)O ADP + phosphate.  
3
  • UniProtKB
 

Keywords

Molecular function 
Chaperone  definition   [KW-0143]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 27348
PRO: PR:O14657