ADAM10 - Disintegrin and metalloproteinase domain-containing protein 10 - human protein (Function)
 
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ADAM10 »  Disintegrin and metalloproteinase domain-containing protein 10   [ EC 3.4.24.81 ]  (ADAM 10)
 
Protein also known as:  Mammalian disintegrin-metalloprotease; CD antigen CD156c.
Gene name:  ADAM10
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.  
8
  • CuratedUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.81: Endopeptidase of broad specificity.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+102  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+102  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Extracellular matrix organization  REACT_118779  
Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor  REACT_2001  
Signal Transduction  REACT_111102  
 
More information is available from:
 

Keywords

Biological process 
Notch signaling pathway  definition   [KW-0914]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAM10
GenomeRNAi: 102
PRO: PR:O14672