ADAM10 - Disintegrin and metalloproteinase domain-containing protein 10 - human protein (Function)
 
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ADAM10 »  Disintegrin and metalloproteinase domain-containing protein 10   [ EC 3.4.24.81 ]  (ADAM 10)
 
Protein also known as:  Mammalian disintegrin-metalloprotease; CD antigen CD156c.
Gene name:  ADAM10
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 198 2
GENE REF ISO

Function

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Overview 
Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.  
9
  • UniProtKB
GO molecular function 
Endopeptidase activitydefinition[GO:0004175]  
1
  • Ortholog Curator
Integrin bindingdefinition[GO:0005178]  
1
  • UniProtKB
Metalloendopeptidase activitydefinition[GO:0004222]  
2
  • UniProtKB
Metallopeptidase activitydefinition[GO:0008237]  
2
  • UniProtKB
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • UniProtKB
  • BHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • Ortholog Curator
Protein kinase bindingdefinition[GO:0019901]  
1
  • Ortholog Curator
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
SH3 domain bindingdefinition[GO:0017124]  
1
  • UniProtKB KW
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • UniProtKB
Constitutive protein ectodomain proteolysisdefinition[GO:0051089]  
1
  • UniProtKB
In utero embryonic developmentdefinition[GO:0001701]  
1
  • Ortholog Curator
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • UniProtKB
Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
8
  • UniProtKB
  • BHF-UCL
Monocyte activationdefinition[GO:0042117]  
1
  • BHF-UCL
Negative regulation of cell adhesiondefinition[GO:0007162]  
2
  • UniProtKB
Notch signaling pathwaydefinition[GO:0007219]  
1
  • Ortholog Curator
PMA-inducible membrane protein ectodomain proteolysisdefinition[GO:0051088]  
1
  • BHF-UCL
Positive regulation of cell growthdefinition[GO:0030307]  
1
  • BHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • BHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • BHF-UCL
Positive regulation of T cell chemotaxisdefinition[GO:0010820]  
1
  • BHF-UCL
Protein phosphorylationdefinition[GO:0006468]  
1
  • Ortholog Curator
Response to tumor necrosis factordefinition[GO:0034612]  
1
  • BHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.81: Endopeptidase of broad specificity.  
1
  • UniProtKB
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+102  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+102  
According to Reactome, this protein belongs to the following pathways:
Activated NOTCH1 Transmits Signal to the Nucleus  REACT_118614  
Collagen degradation  REACT_150401  
Constitutive Signaling by NOTCH1 HD Domain Mutants  REACT_160089  
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant  REACT_160106  
Degradation of the extracellular matrix  REACT_118572  
EPH-ephrin mediated repulsion of cells  REACT_264198  
NOTCH2 Activation and Transmission of Signal to the Nucleus  REACT_160205  
Signaling by EGFR  REACT_9417  
Signaling by NOTCH3  REACT_118862  
Signaling by NOTCH4  REACT_118636  
 
More information is available from:
 

Keywords

Biological process 
Notch signaling pathway  definition   [KW-0914]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAM10
GenomeRNAi: 102
PRO: PR:O14672