PTGES - Prostaglandin E synthase - human protein (Function)
 
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PTGES »  Prostaglandin E synthase   [ EC 5.3.99.3 ]
 
Protein also known as:  Microsomal glutathione S-transferase 1-like 1 (MGST1-L1).
Gene name:  PTGES
Family name: MAPEG
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).  
1
  • CuratedUniProtKB
GO molecular function 
Glutathione bindingdefinition[GO:0043295]  
1
  • IDAUniProtKB
Prostaglandin-E synthase activitydefinition[GO:0050220]  
1
  • IDAUniProtKB
GO biological process 
Acute inflammatory responsedefinition[GO:0002526] silver  
  • IEAOrtholog Compara
Chronic inflammatory responsedefinition[GO:0002544] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Prostaglandin biosynthetic processdefinition[GO:0001516]  
1
  • IDAUniProtKB
Prostaglandin metabolic processdefinition[GO:0006693]  
1
  • TASPINC
Response to calcium iondefinition[GO:0051592] silver  
  • IEAOrtholog Compara
Response to cytokinedefinition[GO:0034097] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
  • IEAOrtholog Compara
Response to retinoic aciddefinition[GO:0032526] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.3.99.3: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.  
1
  • CuratedUniProtKB
It requires the following cofactor
Glutathione.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arachidonic acid metabolism  hsa00590+9536  
Metabolic pathways  hsa01100+9536  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Fatty acid biosynthesis  definition   [KW-0275]
Fatty acid metabolism  definition   [KW-0276]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Prostaglandin biosynthesis  definition   [KW-0643]
Prostaglandin metabolism  definition   [KW-0644]
Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PTGES
GenomeRNAi: 9536
PRO: PR:O14684